The Deafness Variation Database (DVD) is a public, expert-curated resource of genetic variation in genes associated with hearing loss, built and maintained by the Molecular Otolaryngology & Renal Research Laboratories (MORL) at the University of Iowa and launched in 2011.
Our mission is to advance accurate classification of deafness-associated genetic variation by rigorously collating, annotating, classifying, and openly sharing evidence. We aim to reduce uncertainty and enable accurate diagnosis and informed clinical decision-making.
Current release. DVD v9.2 summarizes all known variants across 224 deafness-associated genes represented on OtoSCOPE®, MORL’s comprehensive genetic screening platform for deafness. The DVD collates data from major public resources, annotates with gene/transcript, population, functional, and clinical context, and classifies each variant to produce a single, evidence-based assessment. Classifications are reviewed by genetic hearing-loss experts at the MORL. See sources and our landmark paper, Genomic Landscape and Mutational Signatures of Deafness-Associated Genes for details.
The DVD is continually curated. This version reflects our most recent interpretations.The data are freely available. When using the DVD, please review our citation policy.
All content is copyrighted by the MORL at The University of Iowa.
To suggest an update or add a gene or variant, contact us.
Supported in part by R01 DC012049
Supported in part byR01 DC012049
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