The Molecular Otolaryngology & Renal Research Lab (MORL) Deafness Variation Database (DVD) provides a comprehensive guide to genetic variation in genes known to be associated with deafness. It includes all known genetic variants present in any gene that is included on OtoSCOPE®, the MORL’s comprehensive genetic deafness screening platform. This facilitates variant analysis.
The data in the MORL DVD are based on publicly available data and data from OtoSCOPE®. It also incorporates phenotypic information from the AudioGene machine-learning based audiometric profiling tool.
Variations are organized by gene and categorized as:
- Pathogenic: mutation published in the literature as causing disease
- Probably Pathogenic: classified as such by the dbSNP database
- Unknown Significance: variant reported in dbSNP without a disease association
These data are freely available. When including information from the DVD in publication, please cite this URL and the date accessed. All content is copyrighted by the MORL at The University of Iowa.
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